Serena Williams reveals Zepbound injections helped with 31pound weight loss Anna Kaufman, USA TODAY August 21, 2025 at 10:20 PM Serena Williams is opening up about her experience with GLP1 medications.
- - Serena Williams reveals Zepbound injections helped with 31-pound weight loss
Anna Kaufman, USA TODAY August 21, 2025 at 10:20 PM
Serena Williams is opening up about her experience with GLP-1 medications.
Sometimes dubbed wonder drugs, the injection-format medicines, which include major brand names like Ozempic and Wegovy can assist in major weight loss. Williams, 43, in a new series of interviews, is revealing that GLP-1s are responsible for a recent 31-pound slim down.
"I was on and off (the medication) and now completely on," she told the "Today" show. "It was a really good decision I had to make for my life. I tried everything."
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A tennis great, Williams shared the decision as part of a partnership with healthcare company Ro, which helps get patients access to GLP-1s.
"This all started after I had my (first) kid," Williams added. She shares two children − Olympia, 7, and Adira, 2, with husband Alexis Ohanian. Ohanian is an investor in Ro.
"As a woman, you go through different cycles in your life," Williams said. "No matter what I did − running, walking, I would walk for hours because they say that's good, I literally was playing a professional sport − and I could never go back to where I needed to be for my health. Then, after my second kid, it just even got harder. So then I was like, OK, I have to try something different."
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The tennis star's candor may help to dispel the pesky health innacuracy that weight loss is a simple matter of exercise. While an active life and healthy eating can help with the process, new research suggests that outside factors like genetics may play a bigger role than previously thought. As arguably one of the world's greatest athletes, Williams' decision to share her journey with GLP-1s may help to reshape the image of the drugs.
"A misconception is that it's a shortcut," she said in the interview. "As an athlete and as someone that has done everything, I just couldn't get my weight to where I needed to be at a healthy place − and believe me, I don't take shortcuts."
Williams, who has won 23 Grand Slam titles, went on to imply that the drug may have helped with some wins in her career if she had been taking it earlier.
"I had a lot of knee issues," she told the show. "Especially after I had my kid (and) was never able to get to my normal levels of weight. And that, quite frankly, definitely had an effect on maybe some wins that I could have had in my career." On the new medication, which she later told Vogue was Zepbound, her blood sugar and joint pain have improved, she said.
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While the drugs, which have skyrocketed in popularity and ripped through Hollywood, offered Williams the extra boost she needed, she told Vogue she was aware of how much of a stigma remained.
"I'm not saying any of this lightly, which is why it's so important to have an honest conversation about this topic," she said. "I'm the mom of two girls, and I wanted to be very honest about what I'm doing so they can always be the same with me and we can have an open relationship."
The medications, which work by targeting certain hormones to suppress appetite, have made Williams feel "sexier" and "more confident," she said. And as for those who say if you work hard enough in the gym, you won't need the drugs, Williams says they're misinformed.
"Sometimes you need help. Your story is your story, and it's okay to make that choice to do it if you want to," she told Vogue. "I did, and I'm really happy with it."
This article originally appeared on USA TODAY: Serena Williams is taking Zepbound for weight loss
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